Research Explorer

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Project

Immunopeptidomics-based Development of Next-Generation Bacterial mRNA Vaccines

Outputs & Impact

Publications & research data ( 19 )

MHCquant2 refines immunopeptidomics tumor antigen discovery

Jonas ScheidSteffen LemkeNaomi Hoenisch-GravelAnna DenglerTimo SachsenbergArthur DeclercqRalf GabrielsJens BauerMarcel WackerLeon Bichmann et al.

A1 Journal Article in GENOME BIOLOGY

Target acquired : lock-on bacterial immunopeptides

Patrick WillemsLyudmila KovalchukeFrancis Impens

Editorial material

Sequence simplification of antigen coding IVT mRNA allows accelerated synthetic DNA template generation and epitope immunogenicity validation

Arthur EspritDorien AutaersIlke AernoutIne LentackerSteve PascoloKris ThielemansKarine BreckpotLorenzo Franceschini

A1 Journal Article in MOLECULAR THERAPY NUCLEIC ACIDS

Challenges and opportunities in mRNA vaccine development against bacteria

Ilke AernoutRein VerbekeFabien Henri TheryPatrick WillemsUri EliaStefaan De SmedtRino RappuoliDan PeerFrancis ImpensIne Lentacker

A1 Journal Article in NATURE MICROBIOLOGY

Collisional cross-section prediction for multiconformational peptide ions with IM2Deep

Robbe DevreeseAlireza NameniArthur DeclercqEmmy TerrynRalf GabrielsFrancis ImpensKris GevaertLennart MartensRobbin Bouwmeester

A1 Journal Article in ANALYTICAL CHEMISTRY

Preclinical toxicological assessment of an α-galactosylceramide-adjuvanted mRNA cancer vaccine in Wistar Han rats and domestic pigs

Sofie MeulewaeterMargo De VelderDiethard ReckelbusKevin MwangiThomas EhouarneIlke AernoutYanou EngelenFëllanza HalimiIsis Van herteryckLobke De Bels et al.

A1 Journal Article in MOLECULAR THERAPY METHODS & CLINICAL DEVELOPMENT

Maximizing immunopeptidomics-based bacterial epitope discovery by multiple search engines and rescoring

Patrick WillemsFabien Henri TheryLaura Van MoortelMargaux De MeyerAn StaesAdillah GulLyudmila KovalchukeArthur DeclercqRobbe DevreeseRobbin Bouwmeester et al.

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

TIMS2Rescore : a data dependent acquisition-parallel accumulation and serial fragmentation-optimized data-driven rescoring pipeline based on MS2Rescore

Arthur DeclercqRobbe DevreeseJonas ScheidCaroline JachmannTim Van Den BosscheAnnica PreikschatDavid Gomez-ZepedaJeewan Babu RijalAurelie HirschlerJonathan R. Krieger et al.

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

mRNA galsomes vaccine protects budgerigars against virulent Chlamydia psittaci challenge

Anne De MeystJoeri Van MieghemKoen ChiersKoen RaemdonckRein VerbekeIne LentackerDaisy Vanrompay

A1 Journal Article in VACCINES

Current state of mRNA vaccine development against Mycobacterium tuberculosis

Ilke AernoutRein VerbekeStefaan De SmedtFrancis ImpensIne Lentacker

Bookchapter in Trends in mRNA vaccine research

PTMVision : an interactive visualization webserver for post-translational modifications of proteins

Simon HacklCaroline JachmannMathias Witte PazTheresa Anisja HarbigLennart MartensKay Nieselt

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

Photoporation of NK-92MI cells with biodegradable polydopamine nanosensitizers as a promising strategy for the generation of engineered NK cell therapies

Charlotte HinnekensAranit HarizajDominika BerdeckaIlke AernoutMolood ShariatiStefanie PeetersEva LionStefaan De SmedtBart VandekerckhoveKevin Braeckmans et al.

A1 Journal Article in APPLIED MATERIALS TODAY

Paneth cell TNF signaling induces gut bacterial translocation and sepsis

Charlotte WallaeysNatalia Garcia GonzalezSteven TimmermansJolien VandewalleTineke VanderhaeghenSomara De BeulHester DufoorMelanie EggermontElise MoensVictor Bosteels et al.

A1 Journal Article in CELL HOST & MICROBE

Immunopeptidomics mapping of Listeria monocytogenes T cell epitopes in mice

Adillah GulLecia L. PewePatrick WillemsRupert MayerFabien Henri TheryCaroline AsselmanIlke AernoutRein VerbekeDenzel EggermontLaura Van Moortel et al.

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

Alpha-galactosylceramide improves the potency of mRNA LNP vaccines against cancer and intracellular bacteria

Sofie MeulewaeterIlke AernoutJoke DeprezYanou EngelenMargo De VelderLorenzo FranceschiniKarine BreckpotSerge Van CalenberghCaroline AsselmanKatie Boucher et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

MS²Rescore 3.0 is a modular, flexible, and user-friendly platform to boost peptide identifications, as showcased with MS Amanda 3.0

Louise M. BuurArthur DeclercqMarina StroblRobbin BouwmeesterSven DegroeveLennart MartensViktoria DorferRalf Gabriels

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

Considerations on the design of lipid-based mRNA vaccines against cancer

Sofie MeulewaeterYao ZhangAbishek WadhwaKevin FoxIne LentackerKenneth W. HarderPieter R. CullisStefaan De SmedtMiffy H.Y. ChengRein Verbeke

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Nanobody-mediated SPECT/CT imaging reveals the spatiotemporal expression of programmed death-ligand 1 in response to a CD8+ T cell and iNKT cell activating mRNA vaccine

Thomas ErtveldtSofie MeulewaeterYannick De VlaeminckOscar OlarteKatrijn BroosSerge Van CalenberghStephanie BourgeoisJoke DeprezYves HeremansCleo Goyvaerts et al.

A1 Journal Article in THERANOSTICS

Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures

Sofie MeulewaeterGust NuyttenMiffy H.Y. ChengStefaan De SmedtPieter R. CullisThomas De BeerIne LentackerRein Verbeke

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Activities ( 0 )

Results

Impact narratives ( 1 )

Medicine: vaccines

Area(s): Health

Patents ( 0 )