Code
365O1210
Looptijd
01-01-2011 → 31-12-2012
Financiering
Funding by bilateral agreement (private and foundations)
Promotor
Onderzoeksdisciplines
-
Medical and health sciences
- Laboratory medicine
- Morphological sciences
- Oncology
- Laboratory medicine
- Morphological sciences
- Oncology
- Laboratory medicine
- Morphological sciences
- Oncology
Trefwoorden
transcriptionele repressors
kankergenregulatie
proteomics
tumorcelbiologie
Projectomschrijving
Transgenic mice with conditional expression of Nanos or PUM proteins will be bred to established mouse cancer models in order to analyze the effect of ectopic Nanos/PUM expression on tumor progression. Proteomic changes under the influence of tumor-associated Nanos and PUM will be identified. Transcription factor and miRNA networks regulating the expression of Nanos and PUM will be studied.