Code
365O1210
Duration
01 January 2011 → 31 December 2012
Funding
Funding by bilateral agreement (private and foundations)
Promotor
Research disciplines
-
Medical and health sciences
- Laboratory medicine
- Morphological sciences
- Oncology
- Laboratory medicine
- Morphological sciences
- Oncology
- Laboratory medicine
- Morphological sciences
- Oncology
Keywords
transcriptional repressors
proteomics
cancer gene regulation
tumor cell biology
Project description
Transgenic mice with conditional expression of Nanos or PUM proteins will be bred to established mouse cancer models in order to analyze the effect of ectopic Nanos/PUM expression on tumor progression. Proteomic changes under the influence of tumor-associated Nanos and PUM will be identified. Transcription factor and miRNA networks regulating the expression of Nanos and PUM will be studied.