Project

Special Research Fund grant due to Odysseus fellowship

Code
01ODY116
Duration
01 October 2016 → 30 September 2021
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Proteomics
  • Medical and health sciences
    • Bacteriology
Keywords
Odysseus program pathogenic bacteria
 
Project description

Proteomics-based characterization of the protein interplay between pathogenic bacteria and their host.

Bacterial infections remain a major threat to human health. A better understanding about the fundamental mechanisms used by pathogenic bacteria to infect their host is necessary to identify novel targets for therapeutic intervention. The project presented here aims to further elucidate the complex interaction of intracellular bacterial pathogens with their host on the protein and posttranslational level. This will be achieved by analyzing key processes of bacterial cellular infection through innovative mass spectrometry-based proteome analyses which will provide unprecedented insight into the mechanisms of i) bacterial protein secretion ii) ubiquitin-like protein modification and iii) antigen presentation. Studies will be performed primarily on infection models with Listeria monocytogenes and Salmonella enterica, two major types of foodborne model pathogens causing human disease.