Project

Multi-omics data integration in the context of regulatory networks to decipher regulatory metabolites in complex diseases such as cancer and neuro-inflammatory disorders

Duration
01 November 2020 → Ongoing
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Bioinformatics data integration and network biology
Keywords
gene regulation transcriptomics epigenomics metabolomics clustering dimensionality reduction network inference machine learning benchmarking
 
Project description

First, we will conduct a benchmarking of computational methods for multi-omics data integration. Next, we will develop an improved methodology for multi-omics data integration in the context of regulatory networks to gain in-depth mechanistic insights. Finally, we will apply our methodology to neuro-inflammatory disorders and cancer to identify novel regulators such as regulatory metabolites.