Malignant pleural mesothelioma (MPM) is an asbestos-related disease with dismal prognosis. In order to improve early detection and management, breath analysis of volatile organic compounds (VOCs) as a new, non-invasive diagnostic tool is being explored in our ongoing MesoBreath studies. However, to increase the specificity of the diagnostig breath model, the aim of this MESOBREATH3 study is (I) to compare the VOCs emitted from different MPM cell lines with Ion Mobility Spectrometry (IMS) and identify these VOCs by Gas Chromatography-Mass Spectrometry (GC-MS) (II) correlate VOCs from MPM cells with VOCs in the breath of MPM patients and (III) correlate VOCs with MPM pathogenesis in order to find biological links between the model and the disease pathogenesis