Project

MesoBreath 3: Analysis of Volatile Organic Compounds from mesothelioma cells and pleural effusions with gas chromatography-mass spectrometry (GC_MS) and ion mobility spectrometry (IMS)

Acronym
MesoBreath 3
Duration
01 January 2015 → 31 December 2018
Funding
Funding by bilateral agreement (private and foundations)
Research disciplines
  • Medical and health sciences
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other basic sciences
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other clinical sciences
    • Other health sciences
    • Nursing
    • Other paramedical sciences
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other translational sciences
    • Other medical and health sciences
Keywords
Volatile Organic Compounds
 
Project description

Malignant pleural mesothelioma (MPM) is an asbestos-related disease with dismal prognosis. In order to improve early detection and management, breath analysis of volatile organic compounds (VOCs) as a new, non-invasive diagnostic tool is being explored in our ongoing MesoBreath studies. However, to increase the specificity of the diagnostig breath model, the aim of this MESOBREATH3 study is (I) to compare the VOCs emitted from different MPM cell lines with Ion Mobility Spectrometry (IMS) and identify these VOCs by Gas Chromatography-Mass Spectrometry (GC-MS) (II) correlate VOCs from MPM cells with VOCs in the breath of MPM patients and (III) correlate VOCs with MPM pathogenesis in order to find biological links between the model and the disease pathogenesis