Project

Unlocking Synthetic Biology of Deoxy Sugars via Enzyme Engineering and Biocatalytic Cascades

Duration
01 November 2020 → Ongoing
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
  • Medical and health sciences
    • Carbohydrates
  • Engineering and technology
    • Biocatalysis
    • Biochemical engineering
    • Biocatalysis and enzyme technology
    • Bioprocessing, bioproduction and bioproducts
Keywords
Enzyme engineering biocatalysis dehydratase epimerase deoxysugar
 
Project description

Deoxysugars are important building blocks of several bioactive carbohydrates and derivatives (e.g. glycopeptide antibiotics). Their further exploration is, however, severely hampered by the complex and expensive procedures that are currently required for their production. In this project, new enzymes will be developed and integrated in artificial biosynthetic pathways that make use of sucrose as cheap and abundant starting material.