Project

Phosphorylases as cost-efficient biocatalysts for carbohydrate synthesis: an exploration of natural and mutant diversity

Duration
01 November 2020 → Ongoing
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
  • Medical and health sciences
    • Carbohydrates
  • Engineering and technology
    • Biocatalysis
    • Biochemical engineering
    • Biocatalysis and enzyme technology
    • Bioprocessing, bioproduction and bioproducts
Keywords
glycoside phosphorylase carbohydrate synthesis enzyme engineering
 
Project description

Glycoside phosphorylases are able to synthesize specialty carbohydrates starting from cheap glycosyl phosphates as donor substrates. Unfortunately, the number of available specificities currently is very limited and their products are rarely relevant for the industry. This portfolio will, therefore, be significantly expanded through a combination of state-of-the-art techniques in database mining and enzyme engineering.