Project

Bio-inspired Scaffold Assembly via Intermolecular Cascade Olefin Cyclisations

Duration
01 November 2020 → Ongoing
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
  • Natural sciences
    • Natural products chemistry
    • Organic chemical synthesis
Keywords
Terpenoid Natural Products Cascade reactions Carbocations
 
Project description

Terpenoids, the most diverse specialized metabolites, all share a similar biosynthesis involving cascade reactions resulting in structurally well-defined three-dimensional scaffolds. Terpene scaffolds are usually synthesized via long sequences of fragment-coupling reactions because biomimetic approaches are challenging to achieve. In this project, a hybrid approach towards terpene synthesis will be explored wherein scaffolds can be assembled by designing intermolecular cascade reactions.