Project

Bio-inspired Scaffold Assembly via Intermolecular Cascade Olefin Cyclisations

Code

01D19120

Duration

01 November 2020 → 31 October 2021

Funding

Regional and community funding: Special Research Fund

Promotor

Johan Winne

Fellow

Ellen Demeyere

Research disciplines

Natural sciences
- Natural products chemistry
- Organic chemical synthesis

Keywords

Terpenoid Natural Products Cascade reactions Carbocations

Project description

Terpenoids, the most diverse specialized metabolites, all share a similar biosynthesis involving cascade reactions resulting in structurally well-defined three-dimensional scaffolds. Terpene scaffolds are usually synthesized via long sequences of fragment-coupling reactions because biomimetic approaches are challenging to achieve. In this project, a hybrid approach towards terpene synthesis will be explored wherein scaffolds can be assembled by designing intermolecular cascade reactions.