Code
01D05120
Duration
01 November 2020 → 15 September 2024
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Natural sciences
- (Bio)molecular modelling and design
- Cell signaling
-
Engineering and technology
- Medical molecular engineering of nucleic acids and proteins
Keywords
Bioassay
doping
cancer
HIF-signaling
HIF-stabilizers
dynamics
protein-protein interactions
Project description
This project proposal aims at developing novel 'untargeted' bioassays that allow dynamic monitoring of protein-protein interactions (PPIs) within the oxygen sensing hypoxia-inducible factor (HIF)-pathway. Three PPIs will be studied/targeted in the context of doping and cancer research:
HIF1a-HIF1b heterodimerization, the interaction between HIF1a and the Von Hippel Lindau tumor suppressor protein (pVHL) and the interaction between HIF1a and coactivator p300.