Research Explorer

Project

Triple bioassays for dual purpose: Doping Control & Cancer Research
Code
01D05120
Duration
01 November 2020 → 15 September 2024
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • (Bio)molecular modelling and design
    • Cell signalling
  • Engineering and technology
    • Medical molecular engineering of nucleic acids and proteins
Keywords
Bioassay doping cancer HIF-signaling HIF-stabilizers dynamics protein-protein interactions
 
Project description
 

This project proposal aims at developing novel 'untargeted' bioassays that allow dynamic monitoring of protein-protein interactions (PPIs) within the oxygen sensing hypoxia-inducible factor (HIF)-pathway. Three PPIs will be studied/targeted in the context of doping and cancer research:
HIF1a-HIF1b heterodimerization, the interaction between HIF1a and the Von Hippel Lindau tumor suppressor protein (pVHL) and the interaction between HIF1a and coactivator p300.