01 May 2022 → 30 April 2023
Regional and community funding: Special Research Fund
- Animal genetics
Medical and health sciences
non-coding genome inherited retinal diseases (IRDs) Xenopus tropicalis cis-regulatory elements (CREs) CRISPR/Cas9
Non-coding variants in functional genomic regions such as cis-regulatory elements (CREs) may be implicated in missing heritability of inherited retinal diseases (IRDs). We aim to generate a regulatory map of the genome in retina and perform functional studies of (likely) pathogenic variants of CREs associated with IRD genes in Xenopus tropicalis using transgenic reporters and CRISPR/Cas9 genome editing.