Project

Connexin channels and cell death

Duration
01 January 2009 → 31 December 2014
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Systems biology
  • Medical and health sciences
    • Physiology
    • Physiology
    • Physiology
Keywords
connexins gap junctions hemichannels cell death apoptosis necrosis
 
Project description

Evidence demonstrates that a direct coupling of neighboring cells via gap junction channels can promote the expansion of apoptotic cell death, to which hemichannels (half gap junction) can contribute via a paracrine communication pathway. The aim is to investigate the role of hemichannels and gap junctions in the spread of apoptosis and necrosis, and to identify the modulating signaling molecules.