Project

Targeting the modified innate functionality of the post-asthma alveolar macrophage for relieving Respiratory Syncytical Virus-induced astham exacerbation.

Acronym
365R911
Duration
02 July 2013 → 31 May 2015
Funding
Funding by bilateral agreement (private and foundations)
Research disciplines
  • Medical and health sciences
    • Respiratory medicine
    • Respiratory medicine
    • Respiratory medicine
Keywords
post-asthma alveolar macrophage
 
Project description

Alveolar macrophages residing in the bronchoalveolar lumen of the lungs exhibit after an allergic asthma phase a modified functionality, featuring an increased inflammatory responsiveness to Respiratory Syncytial Virus (RSV) infection, yet exhibit an unaltered antiviral defense. This uncoupling of inflammatory and antiviral responsiveness may well be at the origin of RSV-induced asthma exacerbation and promises a new therapeutic opportunity to be validated through this research project.