RNA stability engineering as a new synthetic biology tool: an HMO case-study

01 January 2017 → 04 March 2022
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Carbohydrates
    • Regulation of metabolism
    • Synthetic biology
    • Microbiology not elsewhere classified
    • Genetics
    • Transcription and translation
  • Engineering and technology
    • Bioprocessing, bioproduction and bioproducts
    • Fermentation
    • Industrial microbiology
    • Industrial biotechnology not elsewhere classified
    • Other biotechnology, bio-engineering and biosystem engineering not elsewhere classified
mRNA stability sialyllactose
Project description

The main objective of this research is twofold. On the one hand it aims for an efficient biotechnological production of human milk sugars (HMOs), which have a clear positive effect on a baby's health and development when added to formula milk. On the other hand, RNA engineering will be investigated as a novel engineering tool. By enhancing the stability of specific transcripts, a lower mRNA turnover rate will be obtained which decreases the need for a high transcription rate and the metabolic burden associated with it.