Research Explorer

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Project

Sensing of viral Z-RNA by ZBP1

Outputs & Impact

Publications & research data ( 7 )

Activation and viral escape of ZBP1-mediated host cell death

Josephine NemegeerJonathan MaelfaitPeter Vandenabeele

Tyramide signal amplification for the immunofluorescent staining of ZBP1-dependent phosphorylation of RIPK3 and MLKL after HSV-1 infection in human cells

Josephine NemegeerKelly LemeirePeter VandenabeeleJonathan Maelfait

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141

Leslie NaesensSantoshi MuppalaDhiraj AcharyaJosephine NemegeerDelfien BogaertJung-Hyun LeeKatrien StaesVeronique DebackerPieter De BleserMarieke De Bruyne et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation

Richard de ReuverSimon VerdonckEvelien DierickJosephine NemegeerEline HessmannSadeem AhmadMaude JansGillian BlanckeFilip Van NieuwerburghAlexander Botzki et al.

A1 Journal Article in NATURE

Viral RHIM proteins antagonise necroptosis by preventing ZBP1-induced RIPK1/RIPK3 amyloid formation in human cells

Josephine NemegeerLeslie NaesensSimon VerdonckEvelien DierickKatrien StaesPeter VandenabeeleJonathan Maelfait

Mutations in RNU7-1 weaken secondary RNA structure, induce MCP-1 and CXCL10 in CSF, and result in Aicardi-Goutières syndrome with severe end-organ involvement

Leslie NaesensJosephine NemegeerFilip RoelensLore VallaeysMarije MeuwissenKatrien JanssensPatrick VerlooBenson OgunjimiDimitri HemelsoetLevi Hoste et al.

A1 Journal Article in JOURNAL OF CLINICAL IMMUNOLOGY

Viral manipulation of host cell necroptosis and pyroptosis

Simon VerdonckJosephine NemegeerPeter VandenabeeleJonathan Maelfait

A1 Journal Article in TRENDS IN MICROBIOLOGY

Activities ( 0 )

Results

Impact narratives ( 0 )

Patents ( 0 )