Research Explorer

Your browser does not support JavaScript or JavaScript is not enabled. Without JavaScript some functions of this webapplication may be disabled or cause error messages. To enable JavaScript, please consult the manual of your browser or contact your system administrator.

Project

Identification of RIPK1 substrates and elucidation of their action mechanism in inflammation

Outputs & Impact

Publications & research data ( 16 )

ATG9A-mediated autophagy prevents inflammatory skin disease by limiting TNFR1-driven STING activation and ZBP1-dependent cell death

Dario PriemJon HuygheBarbara GilbertSimon VerdonckTom DelangheBruno VerstraetenEsther HostePeter VandenabeeleJonathan MaelfaitGeert van Loo et al.

A1 Journal Article in IMMUNITY

TAB2 controls a TAK1-independent cell death checkpoint at the level of TNFR1 complex II in the TNF pathway

Tom DelangheMike VadiAnnelore HaemsLisa WijnsInge BruggemanJon HuygheDario PriemPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Primidone : a clinically promising candidate for the treatment of psoriasis

Theresa RiebelingBenedikt KolbrinkRebecca PhilippsenEileen DahlkeTom DelangheFranziska TheiligAgatha SchwarzRoland SchmittMathieu BertrandUlrich Kunzendorf et al.

A1 Journal Article in CELL DEATH DISCOVERY

RIPK1 is dispensable for cell death regulation in β-cells during hyperglycemia

Onay VeliOyku KayaAna Beatriz VarandaXimena HildebrandtPeng XiaoYann EstornesMatea PoggenbergYuan WangManolis PasparakisMathieu Bertrand et al.

A1 Journal Article in MOLECULAR METABOLISM

Tumor endothelial cell autophagy is a key vascular-immune checkpoint in melanoma

Jelle VerhoevenKathryn A. JacobsFrancesca RizzolloFrancesca LodiYichao HuaJoanna PoźniakAdhithya Narayanan SrinivasanDiede HoubaertGautam ShankarSanket More et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

NINJ1 is activated by cell swelling to regulate plasma membrane permeabilization during regulated necrosis

Yves DondelingerDario PriemJon HuygheTom DelanghePeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH & DISEASE

Beyond ferrostatin-1 : a comprehensive review of ferroptosis inhibitors

Camilla ScarpelliniGreta KlejborowskaCaroline LanthierBehrouz HassanniaTom Vanden BergheKoen Augustyns

A1 Journal Article in TRENDS IN PHARMACOLOGICAL SCIENCES

Cell death checkpoints in the TNF pathway

Jon HuygheDario PriemMathieu Bertrand

A1 Journal Article in TRENDS IN IMMUNOLOGY

Inhibition of RIPK1 kinase does not affect diabetes development : beta-cells survive RIPK1 activation

Tatiana TakiishiPeng XiaoMarie FranchimontEduardo H. GilglioniErick N. ArrobaEsteban N. GurzovMathieu BertrandAlessandra K. Cardozo

A1 Journal Article in MOLECULAR METABOLISM

From PERK to RIPK1 : design, synthesis and evaluation of novel potent and selective necroptosis inhibitors

Camilla ScarpelliniSophie ValemboisKenneth GoossensMike VadiCaroline LanthierGreta KlejborowskaPieter Van der VekenHans De WinterMathieu BertrandKoen Augustyns

A1 Journal Article in FRONTIERS IN CHEMISTRY

LC3-independent autophagy is vital to prevent TNF cytotoxicity

Dario PriemJon HuygheMathieu Bertrand

A1 Journal Article in AUTOPHAGY

Death by TNF : a road to inflammation

Geert van LooMathieu Bertrand

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

ATG9A prevents TNF cytotoxicity by an unconventional lysosomal targeting pathway.

Jon HuygheDario PriemLisette Van HoveBarbara GilbertJ FritschY UchiyamaEsther HosteGeert van LooMathieu Bertrand

A1 Journal Article in SCIENCE

Phosphorylation of RIPK1 serine 25 mediates IKK dependent control of extrinsic cell death in T cells

Sam BlanchettYves DondelingerAlessandro BarbaruloMathieu BertrandBenedict Seddon

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentation

Marine GrosElodie SeguraDerek C. RookhuizenBlandine BaudonSandrine Heurtebise-ChretienNina BurgdorfMathieu MaurinEugene A. KappRichard J. SimpsonPatrycja Kozik et al.

A1 Journal Article in CELL REPORTS

Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor

Tom DelangheJon HuygheSeungheon LeeDario PriemSamya Van CoillieBarbara GilbertSze Men ChoiPeter VandenabeeleAlexei DegterevGregory D. Cuny et al.

A1 Journal Article in CELL DEATH & DISEASE

Activities ( 0 )

Results

Impact narratives ( 0 )

Patents ( 0 )