Code
3F014110
Duration
01 October 2010 → 31 March 2014
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Fellow
Research disciplines
-
Medical and health sciences
- Neurological and neuromuscular diseases
- Neurophysiology
Keywords
pilocarpine
norepinephrine
locus coeruleus
vagus nerve stimulation
temporal lobe epilepsy
Project description
The aim of this project is to elucidate the role of the locus coeruleus and the hippocampal noradrenergic transmission in the anti-epileptic effect of VNS in the intrahippocampal pilocarpine model, and to define the activation of hippocampal noradrenergic transmission as biomarker for efficacy of VNS. Therefore, we make us of selective laesies, specific antagonists and state-of-the-art neurophysiological technics.