The role of the locus coeruleus noradrenergic neurons in the anticonvulsive effect of vagus nerve stimulation (VNS) in the intrahippocampal pilocarpine model.

01 October 2010 → 31 March 2014
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Neurological and neuromuscular diseases
    • Neurophysiology
pilocarpine norepinephrine locus coeruleus vagus nerve stimulation temporal lobe epilepsy
Project description

The aim of this project is to elucidate the role of the locus coeruleus and the hippocampal noradrenergic transmission in the anti-epileptic effect of VNS in the intrahippocampal pilocarpine model, and to define the activation of hippocampal noradrenergic transmission as biomarker for efficacy of VNS. Therefore, we make us of selective laesies, specific antagonists and state-of-the-art neurophysiological technics.