Research Explorer

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Project

Identification of the mechanisms underlying the inter- and intrafamilial phenotypic variability in Osteogenesis Imperfecta, using the zebrafish as a model

Outputs & Impact

Publications & research data ( 3 )

Bmpr1aa modulates the severity of the skeletal phenotype in an fkbp10-deficient Bruck syndrome zebrafish model

Tamara JaraysehSophie DebaenstHanna De SaffelToon RosseelMauro Alessio MilazzoJan Willem BekDavid M HudsonFilip Van NieuwerburghYannick GansemansIván Josipovic et al.

A1 Journal Article in JOURNAL OF BONE AND MINERAL RESEARCH

Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility

Sophie DebaenstTamara JaraysehHanna De SaffelJan Willem BekMatthieu BooneIván JosipovicPierre KibleurRonald Y KwonPaul CouckeAndy Willaert

A2 Journal Article in ELIFE

Lrp5 mutant and crispant zebrafish faithfully model human osteoporosis, establishing the zebrafish as a platform for CRISPR‐based functional screening of osteoporosis candidate genes

Jan Willem BekChen ShochatAdelbert De ClercqHanna De SaffelAnnekatrien BoelJuriaan MetzFrans RodenburgDavid KarasikAndy WillaertPaul Coucke

A1 Journal Article in JOURNAL OF BONE AND MINERAL RESEARCH

Activities ( 0 )

Results

Impact narratives ( 0 )

Patents ( 0 )