This innovative project intends to explore non-thermal plasma polymerization as a single-step, eco-friendly technology to synthesize densely-functionalized polymeric nanoparticles (PNPs) The formation of silicon, silicon carbide, metal and metal oxide nanoparticles in non-thermal plasmas has already been widely explored However, PNP synthesis by means of plasma polymerization of any organic precursor has only been rarely studied, and never in a systematic way, making this a project with a high potential impact To achieve this goal, a highly energetic atmospheric pressure plasma jet (APPJ) as well as a gas aggregation cluster source (GAS) will be constructed 4 different precursors (acrylic acid, vinyl alcohol, pyrrole and 1,3-propanedithiol) will be tested for their PNP synthesis potential in both set-ups To determine their suitability, a systematic exploration of the effect of various plasma parameters on the final properties of the PNPs will be performed Additionally, also the gas phase characteristics will be probed as a function of these plasma parameters enabling us to reveal correlations between the plasma gas phase chemistry and the final properties of the synthesized PNPs, allowing us to translate the data into a roadmap for plasma-assisted PNP production By following this innovative approach, technologically advanced highly functional PNPs will be manufactured and fundamental information on plasma-assisted PNP synthesis will be revealed