Project

Validation of a new animal model for systemic sclerosis and pathophysiological aspects of auto-antibody induction

Duration
01 October 2007 → 30 September 2010
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Orthopaedics
    • Orthopaedics
    • Orthopaedics
Keywords
systemic lupus eryrthematosus and systemic slcerosis anti-nuclear antibodies connective tissue disease lymphotoxin central tolerance
 
Project description

The project starts from the observation that lymphotoxin deficiënt mice develop specific antinuclear antibodies. The aim of the project is to investigate when in the development of mice the absence of lymphotoxin is necessary of the induction of these antibodies, and to verify whether pathological aberrances of connective tissue diseases are present.