Antimicrobial peptides or AMPs are a potential source of new first line defense antibiotics, which often act through the formation of supramolecular assemblies inside the cell membrane, e.g. by pore formation.

In this mutlidisciplinary project a generic synthesis approach will be developed, allowing the production of analogues featuring a number of modifications in composition and stereochemistry. Using recently developed NMR approaches the self-assembly and supramolecular structure will be studied and correlated to the primary sequence, as well as biological activity.