Supramolecular structure-function relationships of antimicrobial peptides from the viscosin group: a combined approach via synthesis and advanced NMR structure analysis

01 October 2011 → 30 September 2015
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Analytical chemistry
    • Organic chemistry
synthesis antibiotics structure analysis
Project description

Antimicrobial peptides or AMPs are a potential source of new first line defense antibiotics, which often act through the formation of supramolecular assemblies inside the cell membrane, e.g. by pore formation.

In this mutlidisciplinary project a generic synthesis approach will be developed, allowing the production of analogues featuring a number of modifications in composition and stereochemistry. Using recently developed NMR approaches the self-assembly and supramolecular structure will be studied and correlated to the primary sequence, as well as biological activity.