Project

Alpha-catenin family members: the search for unique, shared and redundant roles in vivo

Code

3G010409

Duration

01 January 2009 → 31 December 2014

Funding

Research Foundation - Flanders (FWO)

Promotor

Frans Van Roy

Research disciplines

Natural sciences
- Animal biology
- General biology
- Genetics
Agricultural and food sciences
- Veterinary medicine

Keywords

mouse models cell-cell adhesion complexes alpha-catenins

Project description

The major focus of this project will be on the analysis of three sets of mouse models: (1) mice with total or conditional loss of αT-catenin, (2) mice with total or conditional loss of α-catulin, and (3) mice with the replacement of specific isoforms of α-catenins in specific tissues. The ultimate aim is the elucidation of the role of the different α-catenins in different tissues.