Alpha-catenin family members: the search for unique, shared and redundant roles in vivo

01 January 2009 → 31 December 2014
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Animal biology
    • General biology
    • Genetics
  • Agricultural and food sciences
    • Veterinary medicine
mouse models cell-cell adhesion complexes alpha-catenins
Project description

The major focus of this project will be on the analysis of three sets of mouse models: (1) mice with total or conditional loss of αT-catenin, (2) mice with total or conditional loss of α-catulin, and (3) mice with the replacement of specific isoforms of α-catenins in specific tissues. The ultimate aim is the elucidation of the role of the different α-catenins in different tissues.