Determination of intracellular folates by LC-MS/MS in subsets of immune cells

01 January 2012 → 31 December 2014
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Analytical chemistry
  • Medical and health sciences
    • Immunology
    • Immunology
    • Pharmaceutical analysis and quality assurance
    • Immunology
LC-MS/MS folates intracellular
Project description

Folate deficiency has important consequences for the correct functioning of the immune system, with different cell types having different folate requirement and/or a different response following folate deprivation. We aim at evaluating whether these distinct responses of distinct cells of the immune system may be the result of different intracellular concentrations and/or composition of folates. Analyses will be performed by LC-MS/MS.