The dopamine D4 receptor (D4DR) is a G-protein coupled receptor (GPCR). Dopamine is and important neurotransmitter involved in motoric control, reward, endocrine functions, cognition and emotions. In this research we will try to unvravel the mechanisms responsible for the regulation of plasma membrane expressiono f D4DR. This implies research on degradation, endocytosis, recycling and internalisation of D4DR.