Project

Research on the mechanism of regulation of the mature human dopamine D4 receptor

Duration
01 October 2007 → 30 April 2011
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
  • Social sciences
    • Biological and physiological psychology
    • Cognitive science and intelligent systems
    • Developmental psychology and ageing
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Neurosciences
    • Medical biochemistry and metabolism
    • Neurosciences
    • Medical biochemistry and metabolism
    • Neurosciences
Keywords
neurotransmitters GPCR internalisation
 
Project description

The dopamine D4 receptor (D4DR) is a G-protein coupled receptor (GPCR). Dopamine is and important neurotransmitter involved in motoric control, reward, endocrine functions, cognition and emotions. In this research we will try to unvravel the mechanisms responsible for the regulation of plasma membrane expressiono f D4DR. This implies research on degradation, endocytosis, recycling and internalisation of D4DR.