Project

The ins and outs of IRE-1beta signaling

Code

3F003914

Duration

01 October 2014 → 30 September 2018

Funding

Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)

Promotor

Sven Eyckerman

Fellow

Eva Cloots

Research disciplines

Natural sciences
- Biochemistry and metabolism
- Systems biology
Medical and health sciences
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism

Keywords

endogenous tagging IRE-1B mucins UPR

Project description

IRE-1 is an isoform of the unfolded protein response (UPR) sensor IRE-1, with a restricted expression to gut and lungepithelia. Few specific functions have been described for IRE-1, although a role in mucin production has been established. This project focusses on a detailed reconstruction of IRE-1 signaling, using endogenous tagging and protein interaction studies.