Project

The ins and outs of IRE-1beta signaling

Duration
01 October 2014 → 30 September 2018
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
Keywords
endogenous tagging IRE-1B mucins UPR
 
Project description

IRE-1 is an isoform of the unfolded protein response (UPR) sensor IRE-1, with a restricted expression to gut and lungepithelia. Few specific functions have been described for IRE-1, although a role in mucin production has been established. This project focusses on a detailed reconstruction of IRE-1 signaling, using endogenous tagging and protein interaction studies.