Code
3F003914
Duration
01 October 2014 → 30 September 2018
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Fellow
Research disciplines
-
Natural sciences
- Biochemistry and metabolism
- Systems biology
-
Medical and health sciences
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism
Keywords
endogenous tagging
IRE-1B
mucins
UPR
Project description
IRE-1 is an isoform of the unfolded protein response (UPR) sensor IRE-1, with a restricted expression to gut and lungepithelia. Few specific functions have been described for IRE-1, although a role in mucin production has been established. This project focusses on a detailed reconstruction of IRE-1 signaling, using endogenous tagging and protein interaction studies.