Project

Hyperthermic intraperitoneal drug delivery of paclitaxel formulations in a rat model for peritoneal carcinomatosis

Duration
01 January 2009 → 31 October 2013
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
    • Morphological sciences
    • Oncology
Keywords
intraperitoneal perfusion medical imaging chemotherapy
 
Project description

Paclitaxel formulations formulated with cyclodextrins, liposomes and polymer conjugates are in-vitro characterised via solubility, stability and efficiency against tumor cellines. In-vivo the biodistribution, farmacokinetics, tumor penetration and tumor growth delay is determined in a rat model for peritoneal carcinomatosis.