Pharmaceutical development of 1,2,4-trioxane drugs in polymers

01 January 2012 → 31 January 2016
Regional and community funding: IWT/VLAIO
Research disciplines
  • Natural sciences
    • Analytical chemistry
  • Medical and health sciences
    • Tropical medicine
    • Tropical medicine
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutical analysis and quality assurance
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
    • Tropical medicine
artemisinin derivatives hot-melt extrusion
Project description

The main purpose of this research, in collaboration with Dafra Pharma R&D within a Baekeland-funded IWT project, is to develop innovative, patentable formulations resulting in an increased stability and a modified biopharmaceutical profile of the 1,2,4-trioxane derivatives, which meets more the clinical needs, in casu a decreased pharmacokinetic variability and a modified release profile. Polymers will be examined as excipients in their processability with hot-melt extrusion as the preferred manufacturing method for the production of tablets, development of a transdermal system and an implent (e.g. IUD) for several medical applications.