Research Explorer

Project

Implementation of alternative sampling strategies as a tool for studying the etiology and for improving the therapy of Nodding syndrome
Code
01D42414
Duration
01 October 2014 → 30 September 2018
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Analytical chemistry
  • Medical and health sciences
    • Laboratory medicine
    • Laboratory medicine
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutical analysis and quality assurance
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
    • Laboratory medicine
Keywords
Therapeutic Drug Monitoring Bioanalysis
 
Project description

Nodding syndrome is an unexplained, generalized seizure disorder, typically affecting 5-15y old children in subregions of sub-Saharan Africa. We aim at gaining new insights and improving therapy by applying alternative sampling strategies: dried blood spots will be used for therapeutic drug monitoring of antiepileptics, while dried urine spots and hair will be used for validating existing and finding new biomarkers.