Project

Genome wide screening for methylation defects, nonsense mutaions and tumour-related microRNA expression profiles in neuroblastoma

Code
01P07406
Duration
15 October 2007 → 31 December 2010
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Molecular and cell biology
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
    • Molecular and cell biology
    • Morphological sciences
    • Oncology
Keywords
nonsense mutations genome wide neuroblastoma
 
Project description

The aim of the presented study is the identification of the gene defects and signalling pathways that are important in neuroblastoma development and progression. To identify relevant neuroblastoma genes, we will make use of a global methylation analysis, a genome wide screening of nonsense mutations by means of inhibition of the 'nonsense mediated decay' pathway and microRNA profiling.