Project

microRNA profiling of multidrug resistant subpopulations in acute myeloid leukemia

Duration
01 January 2009 → 31 December 2012
Funding
Funding by bilateral agreement (private and foundations)
Research disciplines
  • Natural sciences
    • Systems biology
  • Medical and health sciences
    • Hematology
    • Laboratory medicine
    • Morphological sciences
    • Oncology
    • Hematology
    • Laboratory medicine
    • Morphological sciences
    • Oncology
    • Hematology
    • Laboratory medicine
    • Morphological sciences
    • Oncology
Keywords
microRNA MDR AML
 
Project description

AML is difficult to treat and frequently relapses are observed which eventually cause a high rate of mortality. It is known that MDR plays an important role in the occurrence of these relapses. We wish to explore whether miroRNAs are relevant regulators of the MDR genes, causing resistant disease.