his project aims to advance personalized Serious Games for Health (SGHs) using the PULSE methodology, a novel co-creation approach. Current SGH design is costly and complex, often tailored to specific cases without a unified method for reusability and personalization. PULSE seeks to address this by enabling the systematic evaluation of personalization strategies and improving the transferability of stakeholder knowledge. The project will develop a proof-of-concept SGH for personalized emotion regulation (ER) support for children with Autism Spectrum Disorder (ASD). Due to ASD's heterogeneity, a personalized approach is essential. SGHs can provide tailored, engaging interventions that meet individual needs, overcoming traditional therapeutic limitations. Additionally, the research aims to formalize domain knowledge in an ontology, contributing to the development of SGHs and a better understanding of ASD.