Project

Understanding and exploiting glycosylation in immunotherapy.

Duration
01 January 2017 → 31 October 2021
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Infectious diseases
    • Virology
    • Pathophysiology
    • Vaccinology
    • Vaccines
  • Engineering and technology
    • Medical biotechnology not elsewhere classified
Keywords
vaccines glycosylation pathway engineering
 
Project description

Many vaccine proteins are extensively modified with sugars (glycans), but it has been difficult until recently to produce pure glycoforms of such vaccine proteins. This has obstructed the targeted engineering of the sugar structures for studying and improving vaccine efficacy. New biotechnology being developed at Ghent University overcomes this research bottleneck, which may lead to new vaccines for allergy, flu and worm infections.