Research Explorer

Project

Local Rho kinase inhibition in murine colitis: mode of action
Code
3F014513
Duration
01 October 2013 → 30 September 2017
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Gastro-enterology and hepatology
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other basic sciences
    • Gastro-enterology and hepatology
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other clinical sciences
    • Other health sciences
    • Nursing
    • Other paramedical sciences
    • Gastro-enterology and hepatology
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other translational sciences
    • Other medical and health sciences
Keywords
murine colitis inflammatory bowel diseases ROCK inhibition
 
Project description

Rho kinase (ROCK) inhibition is a possible new target in the treatment of inflammatory bowel diseases (IBD). It is a pleiotropic kinase that plays an important role in inflammation and gut homeostasis and it is overproduced in IBD. This researchproject investigates the effects and molecular mechanisms of locally administrated ROCK inhibitors in murine colitis.