Research Explorer

Project

Systems genetics: studying clonal evolution
Code
01CD15624
Duration
01 November 2024 → 31 May 2025
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Analysis of next-generation sequence data
    • Bioinformatics data integration and network biology
    • General biology not elsewhere classified
Keywords
Bioinformatics network analysis evolution experiments clonal evolution
 
Project description
 The thesis aims at setting up a data analysis platform for pathway-based genotype phenotype mapping in clonal systems (microbial and cancer). By combining experimental or natural evolution with genomics, we will associate the origin of somatic mutations with changes in adaptive behavior in order to identify the genetic mechanism responsible for the adaptive behavior (e.g. resistance to antibiotic selection).