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Project

Identification of the genetic defect in sporadic melorheostosis by means of whole exome sequencing

Outputs and Outcomes

Code

365K0109

Duration

01 January 2009 → 31 December 2009

Funding

Funding by bilateral agreement (private and foundations)

Promotor

Geert Mortier

Research disciplines

Natural sciences
- Genetics
- Systems biology
Medical and health sciences
- Molecular and cell biology
- Molecular and cell biology

Keywords

melorheostosis

Project description

This project aims to identify the genetic defect in sporadic melorheostosis. In addition we aim to gain more insights into the precise role of
LEMD3 in TGFbeta/BMP signaling and regulation of bone density. For this study we will use several approaches including yeast two hybrid
experiments, ChIP-seq, a transgenic mouse model and whole-exome sequencing.

English

Dutch

English

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