Project

(Epi)genetic and environmental determinants of muscle and bone mass in relation to steroid hormones in men

Duration
01 October 2008 → 31 January 2013
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Endocrinology and metabolic diseases
    • Laboratory medicine
    • Medical systems biology
    • Orthopaedics
    • Endocrinology and metabolic diseases
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
    • Orthopaedics
    • Endocrinology and metabolic diseases
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
    • Orthopaedics
Keywords
androgens peak bone mass osteoporosis epigenetics
 
Project description

This study aims to investigate the (epi)genetic determination of peak bone in men. Two large cohorts: (1) a three-generation family-based case-control study including men with idiopathic osteoporosis and their relatives (n=1123), (2) young healthy men (n=768) in a sib-pair design (295 independent families) at age of peak bone mass will be studied. Genetic polymorphisms in the androgen related genes will be studied in relation to volumetric bone mass, body composition (by DEXA), muscle strenght and hormonal status, together with their interreation. Epigenetic inheritance of bone size and density will be studied using selective breeding in animals.