Project

The SOX11 transcription factor as “lineage survival” oncogene in neuroblastoma

Duration
01 October 2013 → 30 September 2017
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
Keywords
SOX11 neuroblastoma Zebrafish model
 
Project description

The SOX11 transcription factor controls essential steps in embryonal development and recently there is an evidence for a crucial role of SOX11 in neuroblastoma pathogenesis. The role of this gene in neuroblastoma tumorigenesis will be further investigated. Furthermore, there will be generated a zebrafish model for the study of the mode of action of this gene, and possible compounds interfering with it.