Research Explorer

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Project

REpurposing lung Surfactant Protein B for Inhalation therapy with RNA therapeutics

Outputs and Outcomes

Publications

Selective replacement of cholesterol with cationic amphiphilic drugs enables the design of lipid nanoparticles with improved RNA delivery

Bram BogaertAliona DebisschopThomas EhouarneHannelore Van EeckhoutteJoyceline De VolderAn JacobsEline PottieRiet De RyckeAurélie CrabbéPieter MestdaghIne LentackerGuy BrusselleChristophe StoveSandra VerstraelenTania MaesKen BrackeStefaan De SmedtKoen Raemdonck et al.

A1 Journal Article in NANO LETTERS

The alpha-adrenergic antagonist prazosin promotes cytosolic siRNA delivery from lysosomal compartments

Thijs Van de VyverCristina MunteanIuliia EfimovaDmitri KryskoLynn De BackerStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Repositioning the antihistamine ebastine as an intracellular siRNA delivery enhancer

Cristina MunteanEva BlondeelLaure HarinckKunal PednekarJai PrakashOlivier De WeverJeanne Leblond ChainStefaan De SmedtKatrien RemautKoen Raemdonck

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs

Bram BogaertFelix SauvageRoberta GuagliardoCristina Muntean[missing] Van Phuc NguyenEline PottieMike WelsAn-Katrien MinnaertRiet De RyckeQiangbing YangDan PeerNiek SandersKatrien RemautYannis M. PaulusChristophe StoveStefaan De SmedtKoen Raemdonck et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Modulating intracellular pathways to improve non-viral delivery of RNA therapeutics

Thijs Van de VyverStefaan De SmedtKoen Raemdonck

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS

Pulmonary surfactant as a versatile biomaterial to fight COVID-19

Lore HermanStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE