Research Explorer

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Project

REpurposing lung Surfactant Protein B for Inhalation therapy with RNA therapeutics

Outputs & Impact

Publications & research data ( 9 )

Surfactant protein B-derived peptides as endosomal escape enhancers for pulmonary delivery of siRNA

Lore HermanRoberta GuagliardoAgata ZamborlinQiaoyu LiuJesús Pérez-GilStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Beyond chloroquine : cationic amphiphilic drugs as endosomal escape enhancers for nucleic acid therapeutics

Aliona DebisschopBram BogaertCristina MunteanStefaan De SmedtKoen Raemdonck

A1 Journal Article in CURRENT OPINION IN CHEMICAL BIOLOGY

Evaluating β2-agonists as siRNA delivery adjuvants for pulmonary surfactant-coated nanogel inhalation therapy

Pieterjan MerckxGRIET CONICKXEvy BlommeTania MaesKen BrackeGuy BrusselleStefaan De SmedtKoen Raemdonck

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Selective replacement of cholesterol with cationic amphiphilic drugs enables the design of lipid nanoparticles with improved RNA delivery

Bram BogaertAliona DebisschopThomas EhouarneHannelore Van EeckhoutteJoyceline De VolderAn JacobsEline PottieRiet De RyckeAurélie CrabbéPieter Mestdagh et al.

A1 Journal Article in NANO LETTERS

The alpha-adrenergic antagonist prazosin promotes cytosolic siRNA delivery from lysosomal compartments

Thijs Van de VyverCristina MunteanIuliia EfimovaDmitri KryskoLynn De BackerStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Repositioning the antihistamine ebastine as an intracellular siRNA delivery enhancer

Cristina MunteanEva BlondeelLaure HarinckKunal PednekarJai PrakashOlivier De WeverJeanne Leblond ChainStefaan De SmedtKatrien RemautKoen Raemdonck

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs

Bram BogaertFelix SauvageRoberta GuagliardoCristina Muntean[missing] Van Phuc NguyenEline PottieMike WelsAn-Katrien MinnaertRiet De RyckeQiangbing Yang et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Modulating intracellular pathways to improve non-viral delivery of RNA therapeutics

Thijs Van de VyverStefaan De SmedtKoen Raemdonck

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS

Pulmonary surfactant as a versatile biomaterial to fight COVID-19

Lore HermanStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Activities ( 0 )

Results

Impact narratives ( 1 )

Medicine: pulmonary disease

Area(s): Health

Patents ( 0 )