Cell-based delivery of adenosine in the hippocampus of a mouse model for temporal lobe epilepsy

01 October 2011 → 30 September 2015
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Other biological sciences
  • Social sciences
    • Biological and physiological psychology
    • Cognitive science and intelligent systems
    • Developmental psychology and ageing
  • Medical and health sciences
    • Neurosciences
    • Neurosciences
    • Neurosciences
  • Engineering and technology
    • Biomaterials engineering
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Other (bio)medical engineering
    • Environmental engineering and biotechnology
    • Industrial biotechnology
    • Other biotechnology, bio-engineering and biosystem engineering
temporal lobe epilepsy cell-based delivery adenosine neural stem cells
Project description

For temporal lobe epilepsy (TLE) patients who cannot be treated with the cuurently available treatments, local delivery of adenosine in the epileptic hippocampus might present a solution. Through video-EEG monitoring this project aims to evaluate the anti-epileptic effects of intrahippocampal adenosine delivery by adenosine producing neural stem cells, originating from men or mice, in the intrahippocampal kainic acid mouse model for TLE.