Research Explorer

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Project

Study of Z-RNA in antiviral programmed cell death and immune dysregulation

Outputs and Outcomes

Publications

Novel insights into double-stranded RNA-mediated immunopathology

Richard de ReuverJonathan Maelfait

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

The Z-nucleic acid sensor ZBP1 in health and disease

Jonathan MaelfaitJan Rehwinkel

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Tyramide signal amplification for the immunofluorescent staining of ZBP1-dependent phosphorylation of RIPK3 and MLKL after HSV-1 infection in human cells

Josephine NemegeerKelly LemeirePeter VandenabeeleJonathan Maelfait

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141

Leslie NaesensSantoshi MuppalaDhiraj AcharyaJosephine NemegeerDelfien BogaertJung-Hyun LeeKatrien StaesVeronique DebackerPieter De BleserMarieke De BruyneElfride De BaereMichiel van GentGuanQun LiuBart LambrechtJens StaalTessa KerreRudi BeyaertJonathan MaelfaitSimon TavernierMichaela U. GackFilomeen Haerynck et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation

Richard de ReuverSimon VerdonckEvelien DierickJosephine NemegeerEline HessmannSadeem AhmadMaude JansGillian BlanckeFilip Van NieuwerburghAlexander BotzkiLars VereeckeGeert van LooWim DeclercqSun HurPeter VandenabeeleJonathan Maelfait et al.

A1 Journal Article in NATURE

Mutations in RNU7-1 weaken secondary RNA structure, induce MCP-1 and CXCL10 in CSF, and result in Aicardi-Goutières syndrome with severe end-organ involvement

Leslie NaesensJosephine NemegeerFilip RoelensLore VallaeysMarije MeuwissenKatrien JanssensPatrick VerlooBenson OgunjimiDimitri HemelsoetLevi HosteLisa RoelsMarieke De BruyneElfride De BaereJo Van DorpeAmélie DendoovenAnne SiebenGillian I. RiceTessa KerreRudi BeyaertCarolina UggentiYanick J. CrowSimon TavernierJonathan MaelfaitFilomeen Haerynck[missing] Program for Undiagnosed Rare Diseases (UD-PrOZA) et al.

A1 Journal Article in JOURNAL OF CLINICAL IMMUNOLOGY

Viral manipulation of host cell necroptosis and pyroptosis

Simon VerdonckJosephine NemegeerPeter VandenabeeleJonathan Maelfait

A1 Journal Article in TRENDS IN MICROBIOLOGY