Hematologic neoplasms pose a major medical problem worldwide and account for ~10% of new cancer cases diagnosed in the developed countries. The twinning NEXT_LEVEL project proposal aims at strengthening scientific and innovation capacity of the Institute of Human Genetics, Polish Academy of Sciences (IHG PAS) located in Poznan (Poland) in the field of hemato-oncology. For this, the IHG PAS will establish strong links with three internationally leading research institutions: University Medical Center Groningen (University of Groningen, the Netherlands), Center for Medical Genetics Ghent (Ghent University, Belgium) and the Institute of Human Genetics, University Hospital of Ulm (Germany). The main objective of the NEXT_high_LEVEL proposal is to step up the research excellence of the IHG PAS in hematooncology and upgrade its position in the international interdisciplinary environment. The project will enable efficient transfer of expertise from the advanced EU laboratories to staff members of the IHG PAS, by strengthening existing ties and establishing new links between the partner institutions. This will be achieved through transfer of best practices from partner institutions, facilitated by joint conference attendance and workshop organization, focused staff training stays, expert visits, cooperative publishing and outreach activities. This will lead to the increase of IHG’s chances to join current European initiatives aimed at understanding hematologic neoplasms. The expected long-term impact of the twinning action is to strengthen the IHG PAS both as a competitor and collaborator within the European Research Area, while simultaneously boosting regional specializations of the Wielkopolska region.