Project

BIOREACTOR: Network biology of stress responses and cell flocculation of Saccharomyces cerevisiae grown in a continuous bioreactor in microgravity conditions

Acronym
BIOREACTOR
Duration
01 January 2012 → 31 December 2015
Funding
Federal funding: various
Research disciplines
  • Natural sciences
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Laboratory medicine
    • Microbiology
    • Laboratory medicine
    • Laboratory medicine
    • Microbiology
Keywords
S. cerevisiae
 
Project description

Yeast cultivation will be performed in a specifically designed continuous bioreactor. An integrative-expermental approach will be used to assess the effect of microgravity. Therefore, various omics technologies, i.e. fluxomics, transcriptomics, proteomics and genomics, and specific cell analysis methods will be used to analyse the samples. A network biology model for S.cerevisiae will be set-up to process the omics data. This will lead to insight into how gravity influences global regulation of energy metabolism, (stress) signaling transduction pathways, transcriptional regulatory networks, gene regulatory networks, protein-protein interaction networks, and metabolic networks.