Project

The role of long noncoding RNAs in T-cell acute lymphoblastic leukemia

Code

3F031612

Duration

01 October 2012 → 30 September 2016

Funding

Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)

Promotor

Franki Speleman

Fellow

Annelynn Wallaert

Research disciplines

Medical and health sciences
- Laboratory medicine
- Medical systems biology
- Laboratory medicine
- Medical systems biology
- Molecular and cell biology
- Laboratory medicine
- Medical systems biology
- Molecular and cell biology

Keywords

NOTCH1 long non-coding RNAs T-cell acute lymphoblastic leukemia

Project description

This project exists of four objectives: (1) enlarge the existing microRNA-messengerRNA network in T-ALL and search for long non-coding RNAs with a role in T-ALL, (2) investigate the direct transcriptional control of NOTCH1 on long non-coding RNA expression, (3) identify NOTCH1/lncRNA/miRNA networks and (4) performing functional in vitro and in vivo studies on the selected long-noncoding RNAs.