Code
3F007112
Duration
01 October 2012 → 30 September 2016
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Fellow
Research disciplines
-
Natural sciences
- Animal biology
-
Medical and health sciences
- Diagnostics
- Laboratory medicine
- Urology and nephrology
- Diagnostics
- Laboratory medicine
- Urology and nephrology
- Medicinal products
- Diagnostics
- Laboratory medicine
- Urology and nephrology
-
Agricultural and food sciences
- Veterinary medicine
- Other veterinary sciences
- Other agricultural, veterinary and food sciences
Keywords
chitinase
intensive care
biomarker
acute kidney injury
sepsis
Project description
Up to 2/3 of human intensive care patients develop acute kidney injury (AKI), which is independently associated with hospital-mortality. In canine patients, AKI is also accociated with a high mortality. Urinary chitinase (3-like) proteins are promising AKI biomarkers in our mouse sepsis model. Their genesis, function and processing in preclinical, as well as their diagnostic value in clinical conditions, are investigated.