Stereoselective synthesis of β-lactams and their use in multicomponent reactions

01 October 2013 → 30 September 2017
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Organic chemistry
multicomponent reactions stereoselective synthesis oxirane β-lactams chiral induction
Project description

This project aims at the synthesis of chiral bi- and tricyclic β-lactams as new antibacterial agents and β-lactamase inhibitors. These goals will be achieved by linking β-lactam chemistry to the chemistry of multicomponent reactions, i.e., the Passerini, Ugi and Strecker reaction, on the one hand and to the chemistry of oxiranes on the other.