Bioceramic materials in the regeneration of dentine-pulp complex

18 March 2022 → 17 March 2026
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Cell signaling
  • Medical and health sciences
    • Oral medicine and pathology
    • Dental materials and equipment
    • Stem cell biology
    • Tissue engineering
Bioceramic materials Dentine regeneration Regenerative endodontic therapy Deep caries
Project description

Bioceramic materials, namely, Tricalcium silicate-based cements (TCSC) are known to induce dental pulp stem cell differentiation regulated by a complex network of signalling molecules, pathways, receptors, and transcription control systems. Moreover, TCS cements have now gained great attention within caries management for their biomineralisation (biomemetics) ability as an expression of bioactivity where demineralised dentine tissue could be remineralised. The molecular biology that controls the action mechanism of TCSC remains unclear. This research aims to explore the underlying mechanism in detail and consequently lead to the development of enhanced biomaterials for successful regeneration of dentine-pulp complex.