The surfactome and exoproteome as a tool to gain insights in the pathogenesis of Clostridium perfringens associated necrotic enteritis in broiler chickens

01 September 2015 → 30 June 2020
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal biology
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Laboratory medicine
    • Microbiology
    • Laboratory medicine
    • Laboratory medicine
    • Microbiology
  • Agricultural and food sciences
    • Agricultural animal production
    • Veterinary medicine
    • Other veterinary sciences
    • Other agricultural, veterinary and food sciences
clostridium perfringens vaccine necrotic enteritis
Project description

The project aims to determine the surfactome and exoproteome of Clostridium perfringens in vitro after contact with chicken gut epithelial cells and at necrotic lesions in the gut of broiler chickens. Genes encoding proteins that are highly expressed under these conditions will be mutated and their role in the pathogenesis evaluated in in vivo.