Unraveling the Regenerative Potential of (Equine) Mesenchymal Stem Cells in a Representative in vitro Tendon Injury Model.

01 October 2021 → 31 October 2021
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal cell and molecular biology
  • Medical and health sciences
    • Stem cell biology
  • Agricultural and food sciences
    • Animal health engineering
In vitro tendon injury model Pathophysiological metabolic pathways MSC secretome
Project description

Equine tendon- and endothelial cells are combined with crosslinkable 3D-printable gelatin hydrogels to establish a representative tendinopathy model after mechanical stimulation. A first screening will be performed to identify metabolites and their pathways involved in tendon (patho-)physiology. Subsequently, the regenerative role of mesenchymal stem cell (MSC) versus fibroblast secretome on these metabolites and their pathways will be evaluated in vitro.